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Resveratrol Ultra


(Product No. 157536)

Manufactured by Integrative Therapeutics, Inc. (ITI)

If you missed the television interviews ...first it was Charlie Rose on PBS (March 28, 2007), next ABC News Barbara Walters special "Live to 150...Can you do it?" (April 1, 2008) and then CBS News Correspondent Morley Safer's 60 Minutes interview with Harvard University researchers (January 25, 2009)...you are -probably wondering "What's all-the excitement about-resveratrol? Isn't it just-another antioxidant?" No, it's much more. While resveratrol certainly has powerful antioxidant action, its effects go far beyond neutralizing free radicals. This natural polyphenolic phytochemical is involved in a number of health-promoting actions within the body. In lower animals and in human cell cultures, resveratrol demonstrates the ability to actually extend life ...healthy life. Scroll down to continue...

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Benefits of Resveratrol
In the past ten years, an abundant number of scientific studies have documented the benefits of resveratrol consumption in the promotion and maintenance of optimal health. This natural polyphenolic phytochemical found in red wine (and other plants) is believed to be the key to the phenomenon referred to as the "French Paradox," which correlates wine intake with a low incidence of cardiovascular disease mortality, despite high intake of saturated fat. Beneficial results have been reported in the following area:

Aging - Resveratrol's anti-aging and life extension benefits are associated with activation of anti-aging genes, sirtuins.

Cardiovascular Health - Resveratrol's positive effects on cardiovascular health are broad and encompass multiple modalities of health promoting actions.

Inflammation - Resveratrol demonstrates a non-selective inhibition of both COX-1 and COX-2, thus signifying an anti-inflammatory effect.

Gastrointestinal Health - Due to its anti-inflammatory properties, resveratrol use has demonstrated beneficial effects on gastrointestinal health.

Antioxidant - Resveratrol has also been shown to be a potent antioxidant due to its ability to increase cellular content of manganese superoxide dismutase (MnSOD)

Menopause - Resveratrol was found to reduce the risk of breast cancer and bone loss m postmenopausal women.

Warning
Both trans-resveratrol and cis-resveratrol isomers are found naturally in resveratrol, however trans-resveratrol is the desirable active ingredient; no benefits have been shown by cis-resveratrol.

If you use resveratrol, be sure the product comes from a reputable source. Some internet companies offer a "free trial", however, after the trial period has ended, it is virtually impossible to cancel future orders and billing. They also cliam to to "freeze dry" or "quick freeze" to obtain maximum effectiveness. There is no study done to back up such claims; these claims are designed with intent to channel customers towards their particular products. Also be sure the product contains the trans-resveratrol in active form and polyphenols from red wine matrix and Japanese knotweed root.

Product Description
Resveratrol Ultra is a nutritional supplement containing high potency resveratrol, a plant compound which research suggests can activate siRT1, an enzyme associated with longevity. Specialized extraction and purification methods provide Resveratrol Ultra with high potency and stability. Made from select red grapes harvested in the south of France, just two capsules of Resveratrol Ultra equals the resveratrol contained in 42 bottles of red wine. Scroll down to continue...

Resveratrol Ultra:
o Contains 3 times more resveratrol per dosage than other leading resveratrol products
o Supports the body's natural anti-inflammatory response
o Provides powerful anti-aging support
o Equals the amount of trans-resveratrol (the most active form of resveratrol) contained in 4 1/2 cases of red wine**

**NOTE: This product contains no alcohol.

Formula
Each 2 capsules contain:
Proprietary Longevity Blend 650 mg
French whole wine grape and giant knotweed root and rhizome extracts containing Resveratrol 125 mg
as 100% trans-resveratrol, the most biologically active form of resveratrol
Japanese Sophora (Sophora japonica) Flower Bud extract 150 mg
standardized to contain 90% rutin

Other ingredients: See label for most current information.

How It Works
Resveratrol
Healthy aging is an emerging research field. Once viewed as an inevitable aspect of life, several interventions have been shown to slow the progression of age-related decline. Considerable evidence has demonstrated that calorie restriction (CR) can increase lifespan, improve stress resistance, and maintain physical function.5,6 Animal studies have consistently shown that mice fed adequate vitamins and nutrients but 40 percent fewer calories, live up to 50 percent longer than mice fed usual diets. Observational research has long held that humans tend to live longer lives when calories are restricted. During times of famine, physiologic and metabolic changes within the human body bring increased survival. However, the obvious hardships associated with CR greatly reduces its acceptance, even by well-motivated individuals.

In the quest to replicate the benefits of CR, resveratrol, a polyphenol found in the skin of grapes and in red wine, has shown the most promise for as an anti-aging antioxidant and supports healthy aging. It is well-known that a moderate intake of alcohol, and red wine in particular, supports heart health. More recently, researchers began to suspect resveratrol might partially explain the so-called French paradox, the puzzling fact that people in France have exceedingly healthy cardiovascular function despite diets high in fat.

While the exact mechanism of action is uncertain, it is thought that resveratrol works primarily in two ways. First, it activates siRT1, a member of the sirtuin class of enzymes, an enzyme associated with longevity. By eliciting an active, highly conserved stress response, siRT1 increases longevity by increasing the ability to survive adversity. Secondly, resveratrol supports healthy mitochondrial production. Mitochondria are cell structures that metabolize glucose and other sugars, a process that naturally generates free radicals and causes increased oxidative stress. Over time, free radicals cause deterioration of the mitochondria themselves, degrading their efficiency and causing heavier production of free radicals. This ongoing, cell-degrading snowball effect is thought to be a major cause of aging. Resveratrol's effect on mitochondria may account for much of the compound's impressive effects in scientific studies so far. As new mitochondria are more efficient than the worn mitochondria they replace, they produce far less free radicals and less oxidative damage.

In 2006, researchers at Harvard Medical School and the National Institute on Aging studied the effect of resveratrol on three groups of middle-aged (one-year-old) mice. One mouse group was fed a diet with 60 percent of calories coming from fat. The second group was given the same high calorie diet, but was also fed resveratrol. The third group acted as a control and received a standard healthy diet.

The results found that the mice who received supplemental resveratrol lived over 30% longer than the mice who also ate the poor diet but did not receive resveratrol. Additionally, the group receiving supplemental resveratrol experienced additional support for liver health and had more mitochondria (essential for cellular energy) than the group who did not receive resveratrol supplementation.

Japanese Sophora (Sophora japonica) Flower Bud
Resveratrol Ultra contains rutin, a potent bioflavonoid from Japanese Sophora (Sophora japonica) Flower Bud. This clinically-studied plant compound possesses free radical scavenging activity and supports healthy collagen. A comparative study of flavonoids found that rutin effectively reduces pain and stiffness due to occasional overuse.Rutin is converted to quercentin in the body. Research suggests that the combination of quercetin and resveratrol provides more potent support for the immune system than either compound alone. Use of super-critical extraction results in Japanese Sophora Flower Bud extract with superior purity, safety, and potency.

Directions
Take 2 capsules daily.

Label Precautions
If you are pregnant, nursing, or taking prescription drugs, consult your healthcare practitioner prior to use.

Contains No
Contains no sugar, salt, yeast, wheat, gluten, corn, soy, dairy products, artificial coloring, artificial flavoring, preservatives, or ingredients of animal origin. This product contains natural ingredients; color variations are normal.

Product Code
o 157536; 60 Capsules

Storage Recommendations
Store at controlled room temperature, 59°F to 86°F (15°C - 30°C).

Other Resveratrol products carried on our site include following:

106_RESV9

Resveratrol-50 120 vcaps

680326

Resveratrol EXTRA 120 caps

680327

Resveratrol 200 mg 60 vcaps

680328

Resveratrol EXTRA 60 caps

6680888

Resveratrol 200 mg 120 vcap

703_RESV8

Resveratrol Synergy 60 vcaps

944_P5514

Extension Resveratrol 300 mg 30 vcaps

944_P5515

Extension Resveratrol 300 mg 90 vcaps


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