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The Role of Estrogen Estrogen is a steroid hormone synthesized from a cholesterol precursor. In premenopausal women, estrogen is primarily synthesized in the ovaries. Small amounts of estrogen are also produced in the adrenal glands, adipose tissue and male testes. Estrone is the predominant estrogen after menopause and estriol, the least potent of the estrogens, is secreted from the placenta during pregnancy and is the peripheral metabolite of estradiol and estrone. The aromatase enzyme present in adipose tissue converts testosterone to estrogen, which is the primary source of estrogen in post-menopausal women.
Estrogen is important for both men and women. In women, estrogen is responsible for growth and development, reproduction, sexualcharacteristics, fat distribution and libido. Estrogen also plays a role in several physiological processes in both sexes, including decreasing bone resorption, maintaining normal vasculature and skin, increasing high density lipoprotein (HDL) cholesterol and triglyceride turnover, influencing water and sodium balance and modulating cognitive function.
Maintaining proper estrogen balance is imperative, however, as estrogens can also have detrimental effects on health. Previous research indicates that womenwho start menses early in life or go through menopause later in life have increased risk of breast cancer due to the prolonged exposure to increased estrogen levels. Via the estrogen receptors, estrogen influences cell proliferation. In target tissues such as the breast and uterus, this estrogen (unopposed by progesterone) may result in hyperplasia, endometriosis, uterine fibroids, fibrocystic breast disease and increased risk of cancer.
In men, testosterone is converted to estrogen via aromatase in adipose tissue, so the more fat tissue a male has, the higher his estrogen level. Too much estrogen in males can lead to erectile dysfunction, sperm abnormalities, gynecomastia and increased risk of testicular and prostate cancers.
Estrogen Balance Long term exposure to estrogens, in the form of hormone replacement therapy or xenoestrogens (estrogen mimics), can have an impact on health. The ratio of estrogen metabolites (e.g., 2-hydroxyestrone over 16-hydroxyestrone) is an established indicator of hormonal balance in women and men, influencing the health of the breast, endometrium, uterus, cervix, prostate and other tissues. Effective estrogen clearance is a growing concern among health care providers, and its implications for gynecologic health and healthy cell development are significant:
Indolplex® contains the key ingredient diindolylmethane (DIM®). DIM is naturally present in cruciferous vegetables such as broccoli. One serving of Indolplex contains an amount of DIM found in approximately two pounds of broccoli. The main role of DIM in the body is to support healthy balance and metabolism of estrogens, which is important for both women and men.† Indolplex utilizes a patented technology that enhances the absorption and bioavailability of DIM.
Take 2 capsules daily with food. If less support is needed, take 1 capsule daily with food, or as recommended by your healthcare practitioner.
Do not use if pregnant or nursing. If taking prescription drugs, consult your healthcare practitioner prior to use. Harmless changes in urine color may occur with the use of this product.
Frequently Asked Questions
Will Indolplex® increase my testosterone levels?
No, Indolplex® will not increase the production of testosterone or any other reproductive hormones. It does, however, balance the ratio of testosterone to estrogen by supporting healthy testosterone metabolism.† As a result, Indolplex® helps maximize your body’s response to weight training and supports increased lean muscle and improved physical conditioning.†
Will Indolplex® cause me to fail urine testing that happens before athletic
No, Indolplex® does not contain any compound that would cause an athlete (or anyone else) to fail urine testing. These tests generally analyze urine sample for anabolic and other steroids, illegal drugs, alcohol, and blood cell enhancers.
How does Indolplex® support healthy estrogen metabolism?
Indolplex®supports, restores, and maintains favorable estrogen metabolism and hormone balance for women in all stages of reproductive health.† This product has a patented delivery system to enhance absorption.† Indolplex® balances and optimizes the ratio of good estrogen metabolites (2-hydroxyestorgen) to bad estrogen metabolites (16-hydroxyestrogen).†
What makes Indolplex® unique?
Indolplex® is formulated with a unique patented technology that enhances its absorption and bioavailability over powder forms of DIM.†
† This statement has not been evaluated by the Food and Drug Administration.This product is not intended to diagnose, treat, cure, or prevent any disease.
Note: Integrative Therapeutics Inc. is among the most respected science based, American dietary supplements manufacturers.
GI Health and Estrogen Estrogen is excreted through the kidneys and via bile into the intestines. Bile salts, and therefore estrogen, are partially reabsorbed back into the body through enterohepatic circulation for recycling. Intestinal bacteria are essential in the deconjugation and transformation of bile acids. Bile salt modifications depend on the species of bacteria in the intestines, as probiotic bacteria can sequester bile acids inhibiting reabsorption.
Research using animal models indicates that supplementation with the probiotic Lactobacillus reduced the reabsorption of bile acids into the enterohepatic circulation and promoted the excretion of acidic steroid hormones in the feces.
This data suggests that optimal gastrointestinal health is linked to balanced estrogen levels.
Estrogen and the Diet Research indicates that diet influences estrogen levels, which may explain, in part, the association between diet and breast cancer. In one study, researchers evaluated the impact of a low-fat/high-fiber diet and a high-fat/low-fiber diet on estrogen metabolism. The investigators found that the women in the high-fat/low-fiber group had significantly higher urinary total estrogens than the subjects in the low-fat/high-fiber diet group.
The researchers state that the high-fat diet results in increased bile reabsorption, resulting in increased reabsorption of biliary estrogens. Furthermore, data suggests that high-fiber diets result in lower blood estrogen levels, likely due to a partial interruption of the enterohepatic circulation of the estrogens by alterations of the intestinal metabolism and reabsorption of these steroids by the fiber.
I3C Versus DIM Increased intake of cruciferous vegetables including cabbage, broccoli, cauliflower, radishes, parsnips, kale and Brussels sprouts, has been shown to decrease overall cancer risk. A constituent of these vegetables, indole-3-carbinol (I3C), exhibits estrogen-modifying and chemo-preventive activity.
I3C also increases the expression of the breast cancer suppression gene BRCA1 and inhibits the activation of estrogen receptors by estradiol, which plays a role in the development of estrogen-enhanced cancers including breast, endometrial and cervical cancers.
In addition, scientists report that I3C suppresses the proliferation of various cancer cell lines including breast, colon, prostate and endometrium.
Research suggests that DIM is the predominant active agent in I3C and cruciferous vegetables. Studies show that DIM binds estrogen receptors inhibiting the binding of estradiol and the growth of breast cancer cell lines by 60 percent.
Conclusion Estrogen is imperative for normal growth and development in both men and women. Excess estrogen, however, has adverse health consequences. Thus, balancing estrogen metabolism by promoting optimal gastrointestinal health and by consuming I3C or DIM can support overall health associated with excess estrogen.