InflaMed combines a synergistic blend of herbs, nutrients and proteolytic enzymes which provide nutritional support for connective tissue and joint tissue. These nutrients have been shown to support the body's regulation within normal levels of some intermediary metabolites, such as cyclooxygenase (COX I & II) enzymes, arachidonic acid, lipoxygenase and leukotrienes.
MSM (methylsulfonylmethane), a major metabolite of DMSO (dimethyl sulfoxide), is a source of biological sulfur, which is a major component in many of the body's proteins, tissues, hormones and enzymes. Sulfur is an essential element of many glycosaminoglycans (GAGs) and is required for the healthy function and structure of joint cartilage. MSM is a natural constituent of a variety of foods and is well absorbed and distributed throughout the body. In addition to its support of GAG synthesis and potential support of healthy connective tissue, MSM may enhance the cellular mucosal membranes.
Indian frankincense (Boswellia serrata) is a large, deciduous tree that grows in the dry, hilly countryside of India. The resinous exudate, an oleogum resin called Salai guggul, has been used for thousands of years in the Ayurvedic (Indian) tradition to support joint and connective tissue health. Recent clinical trials with boswellia gum demonstrated it has potential to support gastrointestinal health as well. The active components, boswellic acids, inhibit 5-lipoxygenase's biosynthesis of leukotrienes.
Turmeric from the root of the southern Asian shrub Curcuma longa is used extensively for color and flavor in curry cuisine. Ayurvedic herbology also includes turmeric in many formulas. Turmeric's key constituent, curcumin, inhibits throm-boxanes and leukotrienes, as well as cyclo-oxygenase-2 and nitric oxide synthase. Curcumin also has antioxidant activity.
Bromelain, a pineapple proteolytic enzyme, is thought to modulate the arachidonate cascade, helping to promote a healthy prostaglandin balance. Ginger (Zingiber officinale) is used in both Ayurvedic and traditional Chinese herbology. Ginger's oleoresin constituents exhibit potent inhibition of the synthesis of prostaglandins and leukotrienes. The components shogaol and paradol inhibit cyclooxygenase-2 enzyme activity dose-dependently, while gingerol inhibits 5-lipoxygenase.
White willow bark (Salix alba), a traditional analgesic and antipyretic, contains salicylates, including salicin and salicylic acid, which is a prime metabolite of aspirin. Salicylates inhibits cyclooxy-genase activity. White willow bark is generally well tolerated by the human gastrointestinal system.
Minerals play important roles in antioxidant enzymes. Molybdenum is essential for sulfite oxidase, required for the detoxification of sulfite to sulfate. Optimum activity of this enzyme is required to detoxify xenobiotics. Selenium is essential for glutathione peroxidase, an important free radical scavenging enzyme. Copper and zinc are essential for superoxide dismutase, another important antioxidant enzyme.