Prima Una de Gato contains cat's claw (Uncaria tomentosa) extract standardized to a minimum of 0.5% pentacyclic oxindole alkaloids (POAs) and is 100% free of tetracyclic oxindole alkaloids (TOAs). Research suggests that the active POAs may affect the immune cells responsible for nonspecific and cellular immunity. Prima Una de Gato also contains quinovic acid glycosides, the natural compounds upon which synthetic quinolones are based. Cat's claw has been used to help promote systemic microbial balance and is thought to support antioxidant activity and circulation. Prima Una de Gato contains added minerals and enzymes to enhance absorption and activity.
Cat's claw, has long been used by indigenous healers in the rainforests of the Peruvian Andes and elsewhere in South America. In recent times it has been studied for its ability to support gastrointestinal and immune functions. Research suggests that in the gastrointestinal tract it can support healthy microbial balance and soothe irritated tissue. Research shows it has antioxidant properties and it may support circulation by strengthening capillaries.
Prima Una de Gato is standardized from whole bark, manufactured using a proprietary process that does not involve the use of solvents. Regular cat's claw contains both pentacyclic oxindole alkaloids (POAs) and tetracyclic oxindole alkaloids (TOAs), whereas Prima Una de Gato is standardized to 0.5% POAs and is 100% free of TOAs. Regular cat's claw typically has a total alkaloid content of 3.0%, with up to 20-25% of that alkaloid content in the form of TOAs.
Why is it important that Prima Una de Gato extract is free of TOAs? TOAs are chemical antagonists that act upon the central nervous system and can greatly inhibit the positive effect of the POAs. The immune enhancement effects of POAa are diminished when the two chemotypes are mixed. Prima Una de Gato, containing only POAs, may have more benefit for immune enhancement than a standard cat's claw containing both pentacyclic and tetracyclic alkaloids.
The POAs are the active ingredients that provide the principal immunomodulating and immuno-stimulating activity and are actively involved in the functional mechanisms of both innate and acquired immunity. In addition, Prima Una de Gato contains quinovic acid glycosides, the natural compounds upon which the synthetic antibiotic quinolones are based.
When TOA-free cat's claw was introduced into Bulgaria, it quickly became the most widely sold natural remedy in that country. TOA-free chemotype cat's claw has been used by Dr. Atanas Tzonkov in Bulgaria's largest private medical clinic, in the nutritional support for thousands of patients. Also in 2001, the Hungarian National Institute of Pharmacy (OGYI), equivalent to the U.S. FDA, approved TOA-free chemotype cat's claw for over-the-counter use.
Prima Una de Gato offers a significant advancement in our understanding of the best utilization of Uncaria tomentosa. The Prima Una de Gato formula is potentized with minerals and enzymes to support detoxification and has been clinically tested. Atanas Tzonkov, director of the Lechitel Clinic in Sofia, Bulgaria, has stated that TOA-free chemotype cat's claw can fortify a person's own self-healing power which Nature has built into his spirit, mind and body.