An effective supplement that has proven to helpreduce low density lipoproteins (LDL- the badcholesterol) while simultaneously raising highdensity lipoproteins (HDL-thegood cholesterol)is pantethine. In study after study, this beneficialsupplement has proven to help patients control theircholesterol levels.
A number of studies focused on a group of peoplewith particular health concerns (i.e. diabetics, perimenopausal,etc.) and in each conclusion, pantethineworked in these health conditions without anydetrimental side effects.
The metabolic activity of pantethine is probably dueto its role in the synthesis of CoA and acyl carrierproteins. CoA is a cofactor in over 70 enzymaticpathways including fatty acid oxidation, carbohydratemetabolism, pyruvate degradation, amino acidcatabolism, heme synthesis, acetylcholine synthesis and phase II detoxification acetylation. ACP is anessential component of the fatty acid synthasecomplex required for fatty acid elongation.
While the exact mechanism of action of pantethine innormalizing parameters associated with dyslipidemiais unknown, several explanations have beenproposed. Some authors have suggested pantethinemight be capable of directly modulating the action ofseveral enzymes involved in cholesterol synthesis.
The efficacy of pantethine in normalizing parametersof dyslipidemia might also be due to its ability toincrease CoA levels. Theoretically, if pantethineenhances the formation of CoA, the additional CoAmight then combine with free acetyl groups to formacetyl-CoA. The acetyl-CoA could then be directedinto the TCA cycle or beta-oxidation at the expenseof cholesterol formation.
In addition to its cholesterol lowering abilities,several human and animal studies have concludedthat pantethine may support other functions,including the healthy metabolism of blood glucose,as well as adrenal and eye health.
Adults take 1 tablet daily with meals or as directedby physician.