The Universal Antioxidant
Description:
Ultra -Lipoic Forte capsules, provided by DouglasLaboratories, contain 1000 mg of pure alpha-lipoicacid per serving. Alpha-lipoic acid is a non-vitamincoenzyme that carries out important metabolic andantioxidant functions in the body.
Health Functions:
Alpha-lipoic acid is a nutritional coenzyme thatparticipates in the energy metabolism of proteins,carbohydrates and fats, with a particular role in bloodglucose disposal. It is also able to scavenge a numberof free radicals.As both a fat and water-soluble, sulfur-containingcoenzyme, alpha-lipoic acid functions in the body aspart of several multi-enzyme complexes located inthe mitochondria. Alpha-lipoic acid is essential formetabolizing carbohydrates, proteins and fats, for theconversion of their energy into ATP. Two of theseenzyme complexes, pyruvate dehydrogenase (PDH)and alpha-ketoglutarate dehydrogenase (KGDH) arepart of the citric acid cycle (Krebs cycle) and as suchassume a central role for general energy production.Another lipoic acid containing enzyme complex,branched-chain keto-acid dehydrogenase(BCKADH), is involved in deriving energy from thebranched chain amino acids, leucine, isoleucine andvaline. A related metabolic function of alpha-lipoic acid isits role in blood glucose disposal. This importantcoenzyme appears to be necessary for the normaltransport of blood glucose into the cell. This may beexplained by its functions in the glucosemetabolizingenzymes, PDH and alpha-KGDH, butsome researchers suspect a more direct role incellular glucose uptake at the cell membrane.As early as 1959, alpha-lipoic acid was suggested tobe an antioxidant, since it could extend the actions ofvitamin C in guinea pigs and those of vitamin E inrats. It is only recently, however, that the specificactions of alpha-lipoic acid in free radical quenching,metal chelation and antioxidant regeneration havebeen investigated. Body cells and tissues are threatened continuously bydamage caused by toxic free radicals and reactiveoxygen species (e.g., peroxides) which are producedduring normal oxygen metabolism and by toxicagents in the environment. Free radicals, onceformed, are capable of disrupting metabolic functionand cell structure. When this occurs, additional freeradicals are produced which, in turn, can result inmore extensive damage to cellular structure andfunction. Alpha-lipoic acid is unique among biologicalantioxidants, because it is soluble in both water andlipids. This allows it to neutralize free radicals justabout everywhere in the body, inside and outside thecells. Due to its unique sulfur-containing structure,alpha-lipoic acid can scavenge several types of freeradicals, such as the highly reactive hydroxyl andsinglet oxygen free radicals. It is also capable ofsuppressing the generation of free radicals in the firstplace, since alpha-lipoic acid chelates transitionmetals, such as iron and copper. Because alphalipoicacid is involved in so many differentantioxidant functions in virtually all body tissues, ithas been called the universal antioxidant.Besides being a universal free radical scavenger,alpha-lipoic acid can also recharge other antioxidantsystems throughout the body. As mentioned earlier,it can extend the activity of vitamins C and E. Inaddition, alpha-lipoic acid can also regenerateglutathione. Ingredients:
Formula (#83005-60X)
3 Capsules Contain:
Alpha Lipoic Acid 1,000 mg.
Servings:
Adults take 3 capsules daily with meals or as directedby physician.
Caution:
No adverse effects have been reported.
Store in a cool, dry place, away from direct light.Keep out of reach of children.
Disclaimer:
The Food and Drug Administration has not evaluated statements contained herein. These products are not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication.
References:
- Ames BN. Micronutrients prevent cancer and delay aging. Toxicol Lett1998;102-103:5-18.
- Anuradha B, Varalakshmi P. Activities of glucose-metabolizing enzymesin experimental neurotoxic models with lipoate as an alleviator. J ApplToxicol 1999;19:405-409.
- Berkson BM. A conservative triple antioxidant approach to the treatmentof hepatitis C. Combination of alpha lipoic acid (thioctic acid), silymarin and selenium: three case histories [In Process Citation]. Med Klin1999;94 Suppl 3:84-9.
- Borcea V, Nourooz-Zadeh J, Wolff SP, Klevesath M, Hofmann M, Urich H,Wahl P, Ziegler R, Tritschler H, Halliwell B, Nawroth PP. alpha-Lipoic aciddecreases oxidative stress even in diabetic patients with poor glycemic controland albuminuria. Free Radic Biol Med 1999;26:1495-500.
- Bustamante J, Lodge JK, Marcocci L, Tritschler HJ, Packer L, Rihn BH.Alpha-lipoic acid in liver metabolism and disease. Free Radic Biol Med1998;24:1023-39.
- Cameron NE, Cotter MA, Horrobin DH, Tritschler HJ. Effects of alphalipoicacid on neurovascular function in diabetic rats: interaction withessential fatty acids. Diabetologia 1998;41:390-9.
- Hagen TM, Ingersoll RT, Lykkesfeldt J, Liu J, Wehr CM, Vinarsky V,Bartholomew JC, Ames AB. (R)-alpha-lipoic acid-supplemented old ratshave improved mitochondrial function, decreased oxidative damage andincreased metabolic rate. Faseb J 1999;13:411-8.
- Jacob S, Ruus P, Hermann R, Tritschler HJ, Maerker E, Renn W,Augustin HJ, Dietze GJ, Rett K. Oral administration of RAC-alpha-lipoicacid modulates insulin sensitivity in patients with type-2 diabetes mellitus:a placebo- controlled pilot trial [In Process Citation]. Free Radic Biol Med1999;27:309-14.
- Jacob S, Streeper RS, Fogt DL, Hokama JY, Tritschler HJ, Dietze GJ,Henriksen EJ. The antioxidant alpha-lipoic acid enhances insulinstimulatedglucose metabolism in insulin-resistant rat skeletal muscle.Diabetes 1996;45:1024-9.
- Kelly GS. Nutritional and botanical interventions to assist with theadaptation to stress. Altern Med Rev 1999;4:249-65.
- Khanna S, Roy S, Packer L, Sen CK. Cytokine-induced glucose uptake inskeletal muscle: redox regulation and the role of alpha-lipoic acid. Am JPhysiol 1999;276:R1327-33.
- Konrad T, Vicini P, Kusterer K, Hoflich A, Assadkhani A, Bohles HJ,Sewell A, Tritschler HJ, Cobelli C, Usadel KH. alpha-Lipoic acidtreatment decreases serum lactate and pyruvate concentrations andimproves glucose effectiveness in lean and obese patients with type 2diabetes. Diabetes Care 1999;22:280-7.
- Lodge JK, Traber MG, Packer L. Thiol chelation of Cu2+ bydihydrolipoic acid prevents human low density lipoprotein peroxidation.Free Radic Biol Med 1998;25:287-97.
- Lykkesfeldt J, Hagen TM, Vinarsky V, Ames BN. Age-associateddecline in ascorbic acid concentration, recycling and biosynthesis in rathepatocytes--reversal with (R)-alpha-lipoic acid supplementation. Faseb J1998;12:1183-9.
- Mitsui Y, Schmelzer JD, Zollman PJ, Mitsui M, Tritschler HJ, Low PA.Alpha-lipoic acid provides neuroprotection from ischemia-reperfusioninjury of peripheral nerve. J Neurol Sci 1999;163:11-6.
- Nagamatsu M, Nickander KK, Schmelzer JD, Raya A, Wittrock DA,Tritschler H, Low PA. Lipoic acid improves nerve blood flow, reducesoxidative stress and improves distal nerve conduction in experimentaldiabetic neuropathy. Diabetes Care 1995;18:1160-7.
- Ou P, Nourooz-Zadeh J, Tritschler HJ, Wolff S. Activation of aldosereductase in rat lens and metal-ion chelation by aldose reductase inhibitorsand lipoic acid. Free Radic Res 1996;25:337-46.
- Packer L. alpha-Lipoic acid: a metabolic antioxidant which regulates NFkappaB signal transduction and protects against oxidative injury. DrugMetab Rev 1998;30:245-75.
- Sen CK, Tirosh O, Roy S, Kobayashi MS, Packer L. A positively chargedalpha-lipoic acid analogue with increased cellular uptake and more potentimmunomodulatory activity. Biochem Biophys Res Commun1998;247:223-8.
- Streeper RS, Henriksen EJ, Jacob S, Hokama JY, Fogt DL, Tritschler HJ.Differential effects of lipoic acid stereoisomers on glucose metabolism ininsulin-resistant skeletal muscle. Am J Physiol 1997;273:E185-91.
- Strokov IA, Kozlova NA, Mozolevskii Iu V, Miasoedov SP, Iakhno NN.[The efficacy of the intravenous administration of the trometamol salt ofthioctic (alpha-lipoic) acid in diabetic neuropathy]. Zh Nevrol PsikhiatrIm S S Korsakova 1999;99:18-22.
- Tomlinson DR. Future prevention and treatment of diabetic neuropathy.Diabetes Metab 1998;24 Suppl 3:79-83.
- Wiznitzer A, Ayalon N, Hershkovitz R, Khamaisi M, Reece EA,Trischler H, Bashan N. Lipoic acid prevention of neural tube defects inoffspring of rats with streptozocin-induced diabetes. Am J ObstetGynecol 1999;180:188-93.
- Ziegler D, Hanefeld M, Ruhnau KJ, Hasche H, Lobisch M, Schutte K,Kerum G, Malessa R. Treatment of symptomatic diabetic polyneuropathywith the antioxidant alpha-lipoic acid: a 7-month multicenter randomizedcontrolled trial (ALADIN III Study). ALADIN III Study Group. Alpha-Lipoic Acid in Diabetic Neuropathy [In Process Citation]. Diabetes Care1999;22:1296-301.
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