Specially formulated to potentiate antioxidant protection
Description:
GSH 250™, capsules, provided by DouglasLaboratories®, contain meaningful amounts ofantioxidant nutrients including glutathione in itsreduced active form, N-acetyl-L-cysteine, abiologically active precursor to intracellularglutathione, alpha-lipoic acid, and selenium.
Health Functions:
Body cells and tissues are threatened continuously bydamage caused by toxic free radicals and reactiveoxygen species (e.g., peroxides) which are producedduring normal oxygen metabolism, by other chemicalreactions, and by toxic agents in the environment. Freeradicals are capable of disrupting metabolic activityand cell structure. When this occurs, additional freeradicals are produced which, in turn, can result in moreextensive damage to cells and tissues. Theuncontrolled production of free radicals is thought tobe a major contributing factor to many degenerativeprocesses seen during aging.Glutathione is a naturally-occurring tripeptide of Lcysteine,L-glutamate and L-glycine. Glutathione is theessential cosubstrate for two major antioxidantenzymes in the body; glutathione peroxidase andglutathione reductase. As such, glutathione offers onemechanism for scavenging toxic free radicals.Glutathione is well absorbed in the intestine, andenters the blood and other extracellular compartmentswhere it exerts much of its beneficial antioxidanteffects. However, it can not effectively enter the cell. N-Acetylcysteine (NAC) is a precursor for the sulfuramino acid cysteine, and cysteine is used by the bodyto synthesize glutathione. In contrast to glutathione,NAC is efficiently transported into the cell where it isreadily converted to L-cysteine for glutathionesynthesis. NAC is well absorbed, and unlikeL-cysteine, is virtually non-toxic. NAC is recognizedas a safe, highly effective means of increasingintracellular glutathione stores. Aside from providingcysteine as a glutathione precursor, NAC also appearsto have antioxidant properties by itself, and is avaluable sulfur donor for various metabolic needs. Alpha-lipoic acid is unique among biologicalantioxidants, because it is soluble in both water andlipids. This allows it to neutralize free radicals justabout everywhere in the body, inside and outside thecells. Due to its unique sulfur-containing structure,alpha-lipoic acid can scavenge several types of freeradicals, such as the highly reactive hydroxyl, andsinglet oxygen free radicals. It is also capable ofsuppressing the generation of free radicals in the firstplace, since alpha-lipoic acid chelates transitionmetals, such as iron and copper. Because alpha-lipoicacid is involved in so many different antioxidantfunctions in virtually all body tissues, it has beencalled the universal antioxidant. Besides being auniversal free radical scavenger, alpha-lipoic acid canalso recharge other antioxidant systems throughout thebody. It can extend the activity of vitamins C and E.and can also regenerate glutathione. Selenium is a cofactor to about 10 selenoproteins inthe body; the most important of these appears to beglutathione peroxidase (GPX). GPX uses glutathioneto reduce hydrogen peroxide and thus protect cells andplasma against free radical injury. GPX activitydepends on an adequate supply of dietary selenium. Ingredients:
Formula (#80691-90X)
3 Capsules Contain:
Glutathione 250 mg, N-acetyl-L-cysteine 250 mg, Alpha-lipoic acid 200 mg, Parsley 150 mg, Spinach 50 mg, Riboflavin 25 mg, Glycine 5 mg, Glutamine 5 mg, Cysteine 5 mg, Selenium 25 mcg.
Servings:
Adults take 3 capsules daily or as directed byphysician.
Caution:
No adverse side effects have been reported.
Store in a cool, dry place, away from direct light.Keep out of reach of children.
Disclaimer:
The Food and Drug Administration has not evaluated statements contained herein. These products are not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication.
References:
- Aruoma OI, Halliwell B, Hoey BM, et al. The antioxidant action ofN-acetylcysteine: its reaction with hydrogen peroxide, hydroxylradical, superoxide, and hypochlorous acid. Free Radic Biol Med1989;6:593-7.
- Best TM, Fiebig R, Corr DT, et al. Free radical activity,antioxidant enzyme, and glutathione changes with muscle stretchinjury in rabbits. J Appl Physiol 1999;87:74-82.
- Borcea V, Nourooz-Zadeh J, Wolff SP, et al. alpha-Lipoic aciddecreases oxidative stress even in diabetic patients with poorglycemic control and albuminuria. Free Radic Biol Med1999;26:1495-500.
- Boya P, de la Pena A, Beloqui O, et al. Antioxidant status andglutathione metabolism in peripheral blood mononuclear cellsfrom patients with chronic hepatitis C. J Hepatol 1999;31:808-14.
- Dringen R, Pfeiffer B, Hamprecht B. Synthesis of the antioxidantglutathione in neurons: supply by astrocytes of CysGly asprecursor for neuronal glutathione. J Neurosci 1999;19:562-9.
- Hagen TM, Ingersoll RT, Lykkesfeldt J, et al. (R)-alpha-lipoicacid-supplemented old rats have improved mitochondrial function,decreased oxidative damage, and increased metabolic rate. Faseb J1999;13:411-8.
- Kagan VE, Shvedova A, Serbinova E, et al. Dihydrolipoic acid--auniversal antioxidant both in the membrane and in the aqueousphase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals.Biochem Pharmacol 1992;44:1637-49.
- Kamei A. Glutathione levels of the human crystalline lens in agingand its antioxidant effect against the oxidation of lens proteins.Biol Pharm Bull 1993;16:870-5.
- Lapenna D, de Gioia S, Ciofani G, et al. Glutathione-relatedantioxidant defenses in human atherosclerotic plaques. Circulation1998;97:1930-4.
- Navarro J, Obrador E, Carretero J, et al. Changes in glutathionestatus and the antioxidant system in blood and in cancer cellsassociate with tumour growth in vivo. Free Radic Biol Med1999;26:410-8.
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